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Name
ID 		C57BL/6J-Snrnp40em1Btlr/Snrnp40swp
MGI:6696345
Phenotype annotations related to immune system
Darker colors indicate more annotations
Mouse Phenotypes
abnormal CD4-positive, alpha-beta T cell physiology
abnormal CD8-positive, alpha-beta T cell physiology
abnormal thymus development
decreased B cell number
decreased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased DN1 thymic pro-T cell number
decreased DN4 thymocyte number
decreased lymphocyte cell number
decreased monocyte cell number
decreased NK cell number
decreased T cell number
decreased T cell proliferation
impaired natural killer cell mediated cytotoxicity
increased central memory CD8 positive, alpha-beta T cell number
increased circulating interferon-beta level
increased circulating interferon-gamma level
increased circulating interleukin-6 level
increased circulating interleukin-12 level
increased circulating interleukin-17 level
increased circulating tumor necrosis factor level
increased effector memory CD8-positive, alpha-beta T cell number
increased susceptibility to viral infection
increased susceptibility to viral infection induced morbidity/mortality
small thymus
thymus hypoplasia
Availability Mouse Genotype
Snrnp40em1Btlr/Snrnp40swp